Dectin2 Effector Reporter Cell(Suspension)
CBP74697
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| I. Background | |
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Dectin-2（又称 CLEC6A）是一种主要表达于单核细胞和巨噬细胞表面的 C 型凝集素受体，属于模式识别受体家族。它顺利获得识别真菌（如白色念珠菌菌丝）表面的 α-甘露聚糖以及尘螨过敏原，与 FcRγ 链结合并激活 Syk-CARD9 信号通路，从而诱导促炎细胞因子（如 IL-23、IL-1β）的产生，在抗真菌免疫和 Th17 细胞分化中发挥关键作用。 |
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| II. Description | |
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Dectin2 Effector Reporter Cell(Suspension) 报告基因药靶模型很好的模拟了体内 Dectin2 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | Dectin2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+ 10% FBS + 1 μg/ml Puromycin + 5 μg/ml Blasticidin + 400 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Recombinant Dectin2 Effector Reporter Cell(Suspension) stably expressing Dectin2.  Figure 2. Dose Response of Dectin2 Agonist Antibody in Dectin2 Effector Reporter Cell (Suspension, C43). |
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